| An infection-based model of neurodevelopmental damage Hornig et al. 96 (21): 12102 Proceedings of the National Academy of Sciences This Article Services Citing Articles Google Scholar PubMed Social Bookmarking | Vol. 96, Issue 21, 12102-12107, October 12, 1999 Neurobiology An infection-based model of neurodevelopmental damage Mady Hornig*, ,
Herbert Weissenböck*, ,
Nigel Horscroft*, and
W. Ian Lipkin*, § * Emerging Diseases Laboratory, Departments of Microbiology and
Molecular Genetics, Anatomy and Neurobiology, and Neurology, University
of California, Irvine, CA 92697-4292; Department of
Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-2649;
and Institute for Pathology and Forensic Veterinary
Medicine, University of Veterinary Medicine, Vienna A-1210, Austria Communicated by James L. McGaugh, University of California,
Irvine, CA, August 19, 1999 (received for review June 9, 1999) Perinatal exposure to infectious agents and toxins is linked
to the pathogenesis of neuropsychiatric disorders, but the mechanisms by which environmental triggers interact with developing immune and
neural elements to create neurodevelopmental disturbances are poorly
understood. We describe a model for investigating disorders of central
nervous system development based on neonatal rat infection with Borna
disease virus, a neurotropic noncytolytic RNA virus. Infection results
in abnormal righting refl...
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